"The recovery in demand in the air transport sector will be slow in the foreseeable future," the airline said.
About 100 aircraft will remain grounded after the crisis, leading to "a total of 22,000 fewer full-time positions in the Lufthansa Group, half of them in Germany".
The posts make up 16 percent of the Lufthansa Group's total workforce of 135,000.
The airline said however that it would look at how it could use schemes for shorter work hours and other crisis arrangements to avoid outright redundancies.
"Without a significant reduction in personnel costs during the crisis, we will miss the opportunity of a better restart from the crisis and risk the Lufthansa group emerging from the crisis significantly weakened," said Michael Niggemann, who heads the airline's human resources and legal affairs departments.